{"id":1109,"date":"2023-05-29T06:49:16","date_gmt":"2023-05-29T06:49:16","guid":{"rendered":"https:\/\/thisbiginfluence.com\/?p=1109"},"modified":"2023-05-29T06:49:17","modified_gmt":"2023-05-29T06:49:17","slug":"special-mediterranean-keto-diet-could-reduce-your-risk-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/thisbiginfluence.com\/?p=1109","title":{"rendered":"Special Mediterranean Keto Diet Could Reduce Your Risk of Alzheimer\u2019s Disease"},"content":{"rendered":"


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A brand new examine carried out by scientists at Wake Forest College College of Drugs signifies {that a} Mediterranean-based ketogenic eating regimen, wealthy in wholesome fat and protein with low carbohydrates, may decrease the chance of Alzheimer\u2019s illness. The researchers discovered that this eating regimen led to important modifications within the intestine microbiome and in a organic pathway associated to Alzheimer\u2019s illness, notably decreasing the degrees of gamma-aminobutyric acid (GABA) and GABA-producing microbes, whereas growing the degrees of GABA-regulating micro organism, suggesting potential advantages for mind well being and dementia prevention.<\/p>\n

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Scientists at Wake Forest University School of Medicine<\/a> have printed a examine suggesting that adhering to a Mediterranean-style ketogenic eating regimen may doubtlessly scale back Alzheimer\u2019s<\/span> disease risk.<\/p>\n

The researchers conducted a comparison between a low-fat diet and a modified Mediterranean ketogenic diet, which consists of healthful fats\/protein and a lower carbohydrate intake. Their findings revealed that this modified diet brought about significant alterations in a biological pathway associated with Alzheimer\u2019s disease.<\/p>\n

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The findings were recently published in Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association<\/em>.<\/p>\n

According to the Alzheimer\u2019s Association, more than 6.5 million Americans are living with Alzheimer\u2019s disease, and 1 in 3 seniors die with the disease or another form of dementia.<\/p>\n

\u201cWe hope that better understanding this complex relationship between diet, cognitive status, and gut health will lead to new interventions to prevent and treat Alzheimer\u2019s disease,\u201d said Suzanne Craft, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine.<\/p>\n

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Suzanne Craft, Ph.D., professor of gerontology and geriatric medicine at Wake Forest University School of Medicine. Credit: Wake Forest University School of Medicine<\/p>\n

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This study builds upon previous research<\/a> from Craft\u2019s team showing that a modified ketogenic diet may prove beneficial in the prevention of cognitive decline.<\/p>\n

The randomized, single-site study involved 20 adults, nine diagnosed with mild cognitive impairment (MCI) and 11 with normal cognition. These participants were randomly assigned to follow either the low-carbohydrate modified Mediterranean-ketogenic diet or a low-fat, higher carbohydrate diet for six weeks then, after a six-week \u201cwashout\u201d period, to switch to the other diet.<\/p>\n

Stool samples were collected from participants at the beginning and end of each diet period, and six weeks after the washout of the second diet to analyze changes in gut microbiome\u2014the good and bad bacteria that live in the gastrointestinal tract.<\/p>\n

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Researchers found that participants with MCI on the modified Mediterranean ketogenic diet had lower levels of gamma-aminobutyric acid<\/span> (GABA) and of GABA-producing microbes. Participants on this diet also had higher levels of GABA-regulating bacteria. GABA is the primary inhibitory neurotransmitter in the central nervous system, and GABA dysfunction is associated with neuropsychiatric conditions including Alzheimer\u2019s disease.<\/p>\n

\u201cOur study is the first to show that diet modulates GABA differently in MCI,\u201d Craft said.<\/p>\n

The study also showed that participants with MCI who had curcumin in their diets also had lower levels of BSH-containing bacteria. These bacteria regulate bile acids produced by the liver and gut. Lower levels suggest reduced gut motility, a phenomenon in which food and waste take longer to transit the gut. Abnormal bile acid profiles have been observed in adults with Alzheimer\u2019s disease.<\/p>\n

\u201cThese findings provide crucial insight into how diet may affect the microbiome and improve brain health,\u201d Craft said. \u201cLarger studies are needed to assess the role diet interventions play in patients with cognitive impairment.\u201d<\/p>\n

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Reference: \u201cEffects of a ketogenic and low-fat diet on the human metabolome, microbiome, and foodome in adults at risk for Alzheimer\u2019s disease\u201d by Amanda Hazel Dilmore, Cameron Martino, Bryan J. Neth, Kiana A. West, Jasmine Zemlin, Gibraan Rahman, Morgan Panitchpakdi, Michael J. Meehan, Kelly C. Weldon, Colette Blach, Leyla Schimmel, Rima Kaddurah-Daouk, Pieter C. Dorrestein, Rob Knight, Suzanne Craft and the Alzheimer\u2019s Gut Microbiome Project Consortium, 5 April 2023, Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association<\/em>.
DOI: 10.1002\/alz.13007<\/a><\/p>\n

The study was funded by the Wake Forest Alzheimer\u2019s Disease Research Center, the Hartman Family Foundation, Roena B. Kulynych Center for Memory and Cognition Research, and the National Institute on Aging.<\/p>\n

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