![\"Dementia](\"https:\/\/scitechdaily.com\/images\/Dementia-Particles-Alzheimers-Brain.jpg\")
<\/a>In a preclinical research, immune cells derived from grownup stem cells had been proven to reverse indicators of neurodegenerative adjustments within the mind.<\/strong><\/p>\n \u201cYounger\u201d immune cells developed by Cedars-Sinai researchers had been capable of reverse indicators of ageing and Alzheimer\u2019s<\/span> disease in the brains of mice, according to findings published in Advanced Science<\/em>. These cells, generated from human stem cells, may one day provide the basis for new therapies to treat neurological disorders in people.<\/p>\n \u201cPrevious studies have shown that transfusions of blood or plasma<\/span> from young mice improved cognitive decline in older mice, but that is difficult to translate into a therapy,\u201d said Clive Svendsen, PhD, executive director of the Board of Governors Regenerative Medicine Institute and senior author of the study. \u201cOur approach was to use young immune cells that we can manufacture in the lab\u2014and we found that they have beneficial effects in both aging mice and mouse models of Alzheimer\u2019s disease.\u201d<\/p>\n The cells in question, known as mononuclear phagocytes, normally travel through the body clearing harmful material, though their effectiveness declines with age.<\/p>\n To generate younger versions of these cells, the team reprogrammed human adult cells into induced pluripotent stem cells, which can be reset to an early embryonic state. From these, they produced new mononuclear phagocytes and infused them into aged mice and mice with Alzheimer\u2019s-like disease.<\/p>\n Mice given the young cells performed significantly better on memory assessments compared with untreated mice. They also retained higher numbers of \u201cmossy cells\u201d in the hippocampus, a brain structure essential for learning and memory.<\/p>\n \u201cThe numbers of mossy cells decline with aging and Alzheimer\u2019s disease,\u201d said Alexendra Moser, PhD, a project scientist in the Svendsen Lab and lead author of the study. \u201cWe did not see that decline in mice receiving young mononuclear phagocytes, and we believe this may be responsible for some of the memory improvements that we observed.\u201d<\/p>\n Mice receiving the young mononuclear phagocytes also had healthier immune cells, called microglia, in their brains. These microglia use long, thin branches to detect and clear debris and damaged cells. The branches shrink and retract due to aging and Alzheimer\u2019s disease, but they remained long and healthy in mice receiving the therapy.<\/p>\n The mechanism behind the effects in the brain remains to be established. As the young mononuclear phagocytes did not appear to enter the brain, investigators believe the cells may have worked indirectly.<\/p>\n The cells could have released antiaging proteins or even tiny particles called extracellular vesicles, which are small enough to enter the brain. Or they could have absorbed pro-aging factors from the blood to keep them out of the brain. The mechanism of protection is the focus of ongoing studies to determine the most effective way to turn these findings into a therapy that could be used in a clinical trial in patients.<\/p>\n \u201cBecause these young immune cells are created from stem cells, they could be used as personalized therapy with unlimited availability,\u201d said Jeffrey A. Golden, MD, executive vice dean for Education and Research. \u201cThese findings show that short-term treatment improved cognition and brain health, making them a promising candidate to address age- and Alzheimer\u2019s disease-related cognitive decline.\u201d<\/p>\n Reference: \u201cHuman iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer\u2019s Disease\u201d by V. Alexandra Moser, Luz Jovita Dimas-Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge and Clive N. Svendsen, 24 August 2025, Advanced Science<\/i>. This work was supported by the Universal Sunlight Foundation, the Cedars-Sinai Center for Translational Geroscience, and the Cedars-Sinai Board of Governors Regenerative Medicine Institute.<\/p>\n Never miss a breakthrough: Join the SciTechDaily newsletter.<\/a><\/b><\/p>\n<\/p><\/div>\nCreating young immune cells<\/h4>\n
Effects on brain health<\/h4>\n
Possible protective mechanisms<\/h4>\n
DOI: 10.1002\/advs.202417848<\/a><\/p>\n